To ensure continuous support and comfort, you should plan to replace your orthopedic slippers every 6 to 12 months, depending on how frequently you wear them. It's time for a new pair when the rubber sole is worn, the cushioned support is inadequate, or the slippers no longer feel as comfortable. Regularly replacing your durable home slippers, especially if you wear them outside or suffer from chronic foot pain, is crucial to maintaining proper foot health.